Nutanix is a great platform for running a range of workloads from small, medium, to large. As disk capacity requirements increase, it can be beneficial to back large data disks (e.g. 1TB+) with multiple smaller virtual disks (vDisks). Although not set in stone, using 4-6 virtual disks instead of one huge disk can significantly boost disk performance with these large data sets. Typically we see this most applicable to database-type workloads, where there is a large working set size and where there can be a lot of write activity. Multiple disks provides more ability to queue I/O requests, additional OPLOG space, and better distrubute high I/O within the Nutanix distributed fabric.